Begin with the person.
Memory. Independence. A familiar face. Define progress through the things that make a life.
Selected reconstructed neuronal branches from human temporal cortex, shown from changing viewpoints.
Human temporal cortexSelected neuronal branches
About the anatomy
An observation, made visible.
Skeleton component 678539249.0 from H01, reconstructed from electron microscopy by Shapson-Coe and colleagues at Harvard University and Google Research. The tissue was removed during epilepsy surgery.
Geometry retained; colour, thickness and movement added for presentation. Public reference anatomy, not research produced by alzh.ai.
A biotechnology company in formation
A future
worth
remembering.
We’re building towards one goal:
a durable cure for Alzheimer’s disease.
Our work starts hereALZH / 001
01 / Our mission
The ambition
is a cure.
Some futures are worth
devoting everything to.
Alzheimer’s reaches into the things that make us who we are. We’re forming a biotechnology company to pursue a future beyond it.
Our starting point is a scientific thesis, a clear standard of evidence, and a search for people who can help move the work forward.
The thinking behind alzh.aiLet evidence lead.
Ask difficult questions. Make uncertainty visible. Earn every claim through the work.
Keep the ambition whole.
Build towards a durable cure. Let that goal guide the people, problems and approaches we bring together.
02 / The questions
Big questions.
First principles.
A starting point for the science.
Explore what is known, what remains open,
and what a cure would have to answer.
Question 01 / 04
What must change to stop the disease?
Which biological processes would a curative intervention need to address?
What the evidence says
A phase 3 donanemab trial found slower clinical decline in people with early symptomatic Alzheimer’s. Both treatment and placebo groups still declined on average.
The open question
Which additional changes, if any, could produce durable disease arrest and meaningful recovery?
These are the questions shaping our thinking. They describe a research direction, not results achieved by alzh.ai.
03 / Field notes
Thinking
in the open.
Ideas, evidence and the questions
that stay with us.
Founding thesis 3 min read
What would it take
to cure Alzheimer’s?
Start by defining the outcome. Then work backwards through the science.
Read the note04 / Build with us
A difficult problem.
Different minds.
Progress starts with a conversation.
We’d like to meet people in neurobiology, therapeutic development, computation and clinical research. Bring a question we should be asking, a result we should understand, or an approach worth examining.
Start a conversation hello@alzh.ai